Seth Rogen, Evan Goldberg
The fact that this type of meta-comedy, where everyone plays exaggerated versions of themselves- plays so well is a tribute to the likability of this gang. The funniest part of the film is the party setpiece that takes up the first twenty-or-so minutes . It's just painfully funny stuff. Once the sci-fi, horror apocalypse stuff kicks in, it's slightly hit and miss, with the emphasis on hit.
Rogen (who also co-wrote and co-directed) with frequent collaborator Evan Goldberg, seems to be well aware of the history of this genre, and it destroys similar comedy-disaster movies like IT'S A DISASTER and RAPTURE-PALOOZA.
Of the cast, the two scene-stealers are without a doubt James Franco, who hilariously plays up his own "self-important" artiste image, and Danny McBride, as the one guy you DON'T want to be with you in the midst of the end of the world. McBride's part leads to the funniest cameo in the film, which I won't spoil here.
The original short that inspired this film, Jay and Seth Vs The Apocalypse is on here too, as is a featurette examining the PINEAPPLE EXPRESS 2 video, and a hilarious five minute bit examining the brilliant cameo that caps off the film.