The Road is at the very top of my list, and for some reason I think it will do quite well at the box-office, although I expect it will get an R rating which may hurt it a bit. Hopefully it gets a wide release so everyone can see it.
I also expect Benjamin Button will do very well at the box-office. The premise is so intriguing and the PG-13 rating will help it. And I don't think the PG-13 is a bad thing at all. The only thing that would have given it an R are the war scenes, and they are very brief.