My favorite dramas of the last 25 years are 24, Lost and The X-Files. I'd love for one of them to be the ultimate winner.
Besides The Wire, I'm sure Mad Men will be up there too. Everybody seems to love that show. Everybody here loves Breaking Bad, but I'm betting instead of Breaking Bad it'll be Mad Men. A final round of Mad Men vs The Wire seems likely to me.
EDIT: Looks like 24 isn't even a contender. Fortunately, Lost is. Unfortunately, they are going to have Lost go up against Mad Men in it's first round.
It also looks like you guys are going to be right about it ultimately going to be Breaking Bad VS The Wire since The Wire and Mad Men will be going up against each other before then. Unless Mad Men actually beats The Wire. Then it would be Mad Men vs Breaking Bad.