I don't think Killing Them Softly was supposed to do huge numbers at the box office anyway. Yes, it didn't make a lot of money - maybe even underperformed - but did anyone expect it to make $100 million?
And not winning an Oscar is not the end of a career? Look at Tom Cruise . . . he's lost a number of times, hasn't been nominated in years, and he's still churning out movies consistently.
And who gives a damn if a commercial has been parodied . . . SNL does it all the time.
I think Brad Pitt is going to be just fine.