In 2004, Baird also started earning acting roles, such as a guest appearance on the Drew Carey Show and in the low-budget film Brain Blockers. Her breakthrough appearance in a major film was in Wedding Crashers in 2005, which she followed up with roles in Accepted and Hot Tamale. In 2006, she appeared in four films, most notably a major role in the horror prequel The Texas Chainsaw Massacre: The Beginning.

Baird had featured photo spreads in several magazines including Playboy, FHM, Stuff, Maxim (in which she was ranked #76 on the Maxim magazine Hot 100 of 2007 list and #64 on the Maxim magazine Hot 100 of 2008 list), Toro and Esquire (UK). She lent her voice to the Scarface video game as one of Tony Montana's possible girlfriends.

Baird guest-starred in episodes of Big Day where her character was known for her large breasts, The Drew Carey Show, Shark, The Loop and Two and a Half Men episode "She'll Still Be Dead At Halftime" (2009).