Bernie Lootz (Macy) is the unluckiest man in Las Vegas… he’s so unlucky, it’s contagious. Looking to knock out their highest rollers, one of the last mob-run casinos in town, the Shangri-La Hotel and Casino downtown, decides to use Bernie as a “cooler” to defuse their lucky streaks. The scheme goes fine until Bernie falls in love with a cocktail waitress, Natalie (Bello), who becomes his “lady luck”, much to the chagrin of the casino’s crooked director (Baldwin) who aims to break up the romance, and Bernie’s newfound luck.