Cox's career as an entertainer started at the age of four, as she appeared as a dancer in several ballet productions and TV specials. She began acting at the age of ten, making appearances in several movies and guest starring on shows such as Baywatch, California Dreams, Star Trek: The Next Generation, and Blossom. She also starred in General Hospital from 1993 to 1995. Her appearances on various TV shows would lead to her first prime-time starring role as Tiffany Malloy on the sitcom Unhappily Ever After, which ran on the WB 1995–1999. After Unhappily left the airwaves, she would portray former prostitute Taylor Clayton on the sitcom The Norm Show and star as Nikki White in Nikki, a sitcom vehicle that would last for less than two seasons (2000–2002). She currently stars as Mary Connell on the TV drama Las Vegas. On 20 May and 23 May 2005, her Las Vegas character crossed over to NBC's cult-favorite soap opera Passions to coincide with the arrival of two new characters introduced on Las Vegas. After being romantically linked to Kevin Connolly, who played her brother on Unhappily Ever After, Cox was engaged in 1999 to Bobcat Goldthwait, a comedian more than 15 years her senior, who played the voice of Mr. Floppy, a stuffed bunny, on Unhappily Ever After. She was later linked to her Las Vegas co-star Josh Duhamel. Cox confirmed on the January 2, 2006, edition of the morning talk show Live with Regis and Kelly that she is in a relationship with comedian/actor Jay Mohr. They were married on December 29, 2006 in Los Angeles.[1] Now she's the model for Sportsbook.com.

• June 2, 2008: 6/02's B-Day Hottie: Let's put aside our traumatizing memories of those recent pictures taken of Nikki Cox looking like a clown face gone wrong and remember the Nikki Cox that used to be. That big breasted, redheaded goddess on...
• May 17, 2008: WTF Nikki?: I used to really like Nikki Cox. Back when she was on "Unhappily Ever After," with those huge sweater puppies of hers. She was a poor man's Christina Applegate clone, the slutty looking sister who really was virginal and smart but still had the...
• February 4, 2006: Nikki and Jay getting married?: Honestly, we had no idea these two were even dating but it's no surprise that Jay Mohr, like Zach Braff, is locking down Nikki Cox before the drugs wear off. Not that he necessarily drugged her into girlfriend submission but her previous paramour...