Chalke was born in Ontario, Canada, and was raised in Vancouver, British Columbia. She is the middle of the three daughters of Doug and Angie Chalke. Her mother is from Rostock, Germany. Chalke maintains contact with her German relatives. According to a Scrubs commentary track, she used to attend the German school in her hometown twice a week. Her first language is English, though she speaks German and French fluently and is a vegetarian. Chalke's acting career began at the age of eight when she began appearing in musical theatre productions. At 16, she became a reporter on the Canadian children's show KidZone. In 1993, she took over the role of Becky (Conner) Healy on Roseanne from Lecy Goranson; she also made a cameo appearance as a different character in the Roseanne episode "Halloween: The Final Chapter" (#178, originally aired October 31, 1995). She returned briefly to Canada where she starred in the CBC Television drama Nothing Too Good for a Cowboy (1998-1999). In 2001, she was cast as Dr. Elliot Reid in the NBC comedy series Scrubs. She has appeared in several feature films, starting with Ernest Goes to School (1994). She also appeared in Channel 101's The 'Bu with The Lonely Island, a parody of the hit show The O.C., but was credited as Pamela Fenton.

• August 17, 2009: Chalke Pregnant?: Holy shit on a stick, the hotties are dropping like flies today! First Alyssa Milano gets married (although the expiration date on that is really undetermined), then Rebecca Gayheart appears in a sex tape with her husband and a disgraced...
• July 20, 2009: Hottie Clip #428: Sarah Chalke & Christa Miller In Hot Bikinis - "SCRUBS"
• June 15, 2009: WIF Aniston Love: On Friday, Jennifer Aniston was honored by the Crystal and Lucy Awards, this Women in Film organization which gave her the Crystal Award, Holly Hunter took home the Lucy Award, director Catherine Hardwicke received the The Dorothy Arzner Directors...
• June 2, 2009: Chalke Can Eat Me: I do not watch the Lifetime Channel. I do not watch the Lifetime Channel. I do not care how cute Sarah Chalke looks in the promos for her two-night mini-series event that they're promoting. I'll just look at the pictures and think that she's hot....
• April 30, 2009: Lesbo Dreams Realized!: As I sit here late at night, browsing through the latest images of the parties that I don't get to go to because they're on a school night, my mind starts to wander. And when it lands on something particularly worth lingering on, chances are there...
• March 12, 2009: Battle of the Babes #43: This week, I tried to figure out a way that I could work in a blonde, a brunette and a red head and still have them all be connected in some really not all that necessary grouping manner like I do. Then I started reading over some...
• January 14, 2009: Hottie Clip #363: Sarah Chalke's Hot Bikini Top In Sex Fantasy - "SCRUBS"
• November 25, 2008: Chalke's Scrubs Promos: Behold....the sexiest actress in sitcom television history! After Christina Applegate in "Married With Children", Sarah Chalke on "Scrubs" is undoubtedly the hottest babe to ever grace a comedy series in my opinion. With that in mind, the 8th...
• October 21, 2008: Premiere: Zack And Miri Make A Porno: With just over a week and a half to go, I couldn't possibly be more friggin' excited for Kevin Smith's latest raunchy, foul-mouthed comedy, "Zack And Miri Make A Porno". After months and months of publicity issues, film rating hurdles and...
• October 10, 2008: Some Like it Chalke: Sarah Chalke, fondly remembered by me as being the "classy Becky" on the show "Roseanne" was out visiting David Letterman the other night and quite frankly looking hot as f*cking hell. I don't know what she was promoting and frankly,...
• June 19, 2008: Hottie Clip #258: Sarah Chalke In Hot Lingerie & Teasing - "CHAOS THEORY"
• June 10, 2008: Hellooo Sarah!: First off, I need a moment to collect myself after watching that new video with Brittany Snow that Cherry posted as she smashes the shit out of a guy's balls. I couldn't possibly imagine how painful that would be and that video almost rivals Ellen...
• July 27, 2007: Chalke Does "Hot Rod"!: This blonde beauty does not get enough work or enough nude scenes in either her movies or T.V. shows. I fell head over heels for this woman when I started watching "Scrubs" and she's been getting higher and higher up my hottie list as time went...