A band of fearless fighters have defeated the evil warlords from Outworld in the life-or-death tournament of Mortal Kombat, saving Earth from destruction for another generation. But as the celebrants rejoice in their triumphant victory, the portals leading to Outworld are ripped asunder, and a giant figure with the face of Death declares that the battle has just begun.

Shao-Kahn, the feared Emperor of Outworld, has broken the sacred rules of Mortal Kombat and is coming in person with his extermination squads to conquer and eliminate anything that stands in his way. The Warriors will have to depend more than ever on their own courage and initiative to stop the fierce and destructive onslaught, fighting against enemies more powerful than any they have ever encountered before.

The stakes are annihilation. And this time, there are no rules.