Greg Focker (Ben Stiller) is head over heels in love with his girlfriend Pam (Teri Polo), and is ready to pop the big question. When his attempt to propose is thwarted by a phone call with the news that Pam’s younger sister is getting married, Greg realizes that the key to Pam’s hand in marriage lies with her formidable father, Jack Byrnes (Robert De Niro).

A trip to New York for her sister’s wedding seems just the right occasion for Greg to ask Pam to be his wife. But everything that could possibly go wrong, does.