Stiller portrays risk-averse Reuben Feffer, whose best-laid plans for life and love careen wildly off track when his bride (Messing) dumps him on their honeymoon for a muscle-bound scuba instructor (Azaria). Stunned, humiliated and in the grip of acute indigestion, Reuben plans to play it safer than ever. But a chance encounter with an adventure-craving, childhood friend named Polly (Aniston) shoots him into a whirlwind of extreme sports, spicy foods, ferrets, salsa dancing and living in the moment.