Set in modern day Los Angeles, Spread is a hard biting story about a high-end lethario, Nikki (Ashton Kutcher), who has slept his way into a life of privilege. He shares his secrets with us as he hosts parties and beds scores of women, all while living it up at the Hollywood Hills home of a middle-aged female attorney, Samantha (Anne Heche). Everything is going swimmingly until Nikki meets a gorgeous waitress named Heather (Margarita Levieva), who, unbeknownst to him, is playing the same game that he is. As the truth of their life unravels, they find themselves sexually charged by a game of one-upsmanship that has them dining at fine restaurants and crashing posh parties, until the truth of their lives forces them to choose between love and money. Inspired by classics like Shampoo, Breakfast at Tiffanys, and America Gigolo, Spread profiles a sexual grifter and his prey.

Los Angeles serves as a character unto its own in this film, providing slick and luxurious backdrops during Nikkis high times, and seedy, fleabag motels when Nikki has nowhere else to turn. Nikki runs the gambit of Hollywood dreams and nightmares. The supporting cast is comprised of gorgeous women like Emily (Rachel Blanchard), who is drawn in by Nikkis good looks and charm but is left feeling cold and used. Nikkis best friend, Harry (Sebastian Stan), struggles with their co-dependant relationship, always needing to bail Nikki out when he runs out of women to depend on.