The film tells the story of Barney Panofsky (Paul Giamatti), an English-speaking Jew from Montreal, who feels in love for the first time of his life. However, it appears that he’ll be married three times. Clara (Rachelle Lefevre), Barney’s first wife, is a beautiful writer, but she’s mentally ill. The second wife (Minnie Driver) left Barney at the time Boogie (Scott Speedman), Barney’s best friend, disappeared. Miriam (Rosamund Pike), the third wife, left Barney for another man and he hopes that she’ll come back to him.