Ghosts of Mississippi is a drama covering the final trial of the assassin, Bryon De La Beckwith (Woods),who on June 12, 1963 ended the life of civil rights activist Medgar Evers. It begins with the murder and the events surrounding the two initial trials which both ended in a hung jury. Nearly thirty-one years would pass before justice would make its peace with Medgar Evers. Through perseverance and faith, his case would be resurrected, and Mississippi along with the world would take a significant step towards atonement as well as racial equality. Some of the characters are played by the actual participants in this story.