Kirsten Dunst will be directed by Lars Von Trier in Melancholia. Poor, poor girl.

Deadline’s Mike Fleming is reporting that Kirsten Dunst, now free from her Spider-Man duties as Mary Jane Watson, will be headlining director/misanthrope Lars Von Trier’s “sci-fi disaster film” MELANCHOLIA.

The actress, likely to be subjected to any number of psychological traumas at the hands of the Danish visionary, will be joined by masochist Charlotte Gainsbourg, the soon to be Bauer-less Kiefer Sutherland, the once terribly alluring Charlotte Rampling, the cool motherf*cker from “Generation Kill” and “True Blood” Alexander Skarsgard, his father Stellan Skarsgard, and iconic cinema weirdo Udo Kier. That’s one hell of a cast that may or may not get their genitalia cut off!

Penelopez Cruz was previously in negotiations for the film’s lead role, but that fell through once the Spanish leading lady took to the high seas with PIRATES OF THE CARIBBEAN: ON STRANGER TIDES.

MELANCHOLIA, said to be a sort of psychological end-of-the-world film, will begin shooting this July in Sweden. Dunst is currently filming the romantic drama UPSIDE DOWN opposite Jim Sturges. Her short film BASTARD, which she directed and co-wrote, will be premiering at the Tribeca Film Festival and was just recently accepted into the Cannes Film Festival.