Interview: Natasha Lyonne, Maya Rudolph and More Talk Second Best Hospital in the Galaxy

Last Updated on February 26, 2024

Are you down for something a little twisted? Well, I may have the cure. The new Prime Video series The Second Best Hospital in the Galaxy is gruesomely hilarious and wonderfully witty. It’s wild and weird and offers up a great cast of characters. The inclusion of Maya Rudolph, Natasha Lyonne, and the Culkin family is truly inspired. And if you want a lot of animated gore, you are in for a bit of a treat here. Showrunner Cirocco Dunlap has done a nice job of creating something new and unique. Recently, I had a very entertaining chat with Natasha Lyonne, Maya Rudolph, and Cirocco Dunlap about their latest. The conversation ran the gamut from bringing such a gruesome nature to the show, as well as centering the series around women. Natasha Lyonne and Maya Rudolph talked about the impressive cast and the colourful characters on display. It was a joy speaking to these three. You can check out the interview in the video embedded above, and if you need a laugh, I recommend you give The Second Best Hospital in the Galaxy on Prime.

This series centers on Sleech and Klak, two brilliant female alien doctors who specialize in rare sci-fi illnesses. In addition to Natasha Lyonne, Maya Rudolph, and Cirocco Dunlap, the voice cast includes Kieran Culkin, Stephanie Hsu, Keke Palmer, Andrew Dismukes, Lennon Parham, Gary Anthony Williams, Sam Smith, Bowen Yang, Phil LaMarr, Greta Lee, Kemah Bob, Abbi Jacobson, Tracee Ellis Ross, Jay Ellis, and Grey Griffin.


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JimmyO is one of’s longest-tenured writers, with him reviewing movies and interviewing celebrities since 2007 as the site’s Los Angeles correspondent.